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Expression of the T4 molecule (AIDS virus receptor) by human brain‐derived cells
Author(s) -
Dewhurst Stephen,
Stevenson Mario,
Volsky David J.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81478-3
Subject(s) - monoclonal antibody , flow cytometry , biology , virology , glycoprotein , virus , microbiology and biotechnology , cell culture , ribonuclease , antibody , receptor , antigen , cell fusion , gene , cell , rna , immunology , genetics
Three human cell lines of astrocytic origin were evaluated for expression of a human T‐lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT‐4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4‐positive and ‐negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.