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Regulatory role of the ATPase inhibitor protein on proton conduction by mitochondrial H + ‐ATPase complex
Author(s) -
Guerrieri Ferruccio,
Scarfò Rosanna,
Zanotti Franco,
Che Yan Wu,
Papa Sergio
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81466-7
Subject(s) - submitochondrial particle , inhibitor protein , atpase , proton , chemistry , mitochondrion , biophysics , proton pump , biochemistry , enzyme , biology , physics , quantum mechanics
This study shows that the natural inhibitor protein of mitochondrial H + ‐ATPase complex (IF 1 ) inhibits, in addition to the catalytic activity, the proton conductivity of the complex. The inhibition of ATPase activity by IF 1 is less effective in the purified F 1 than in submitochondrial particles where F 1 is bound to F 0 . No inhibition of H + conductivity by F 0 is observed in F 1 ‐depleted particles