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Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid
Author(s) -
Halliwell Barry,
Wasil Mohammed,
Grootveld Martin
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81456-4
Subject(s) - hypochlorous acid , ascorbic acid , myeloperoxidase , chemistry , biochemistry , inflammation , anti oxidant , antioxidant , medicine , immunology , food science
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase‐derived oxidant hypochlorous acid at rates sufficient to protect α 1 ‐antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.