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Modulation of superoxide dismutase by electron donors and acceptors
Author(s) -
Gulyaeva Natalia V.,
Obidin Andrey B.,
Marinov Beniamin S.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81438-2
Subject(s) - superoxide dismutase , chemistry , modulation (music) , biophysics , photochemistry , biochemistry , enzyme , biology , physics , acoustics
The competition between superoxide dismutase (SOD) and nitroblue tetrazolium (NBT) for O 2 − radicals in the presence of a number of physiologically active compounds was studied. The Na + channel blockers, ajmaline, tetracaine, bipuvacaine, lidocaine and etmozine produced an increase in the amount of O 2 − reacting with SOD. Nitroprusside, ferricyanide, BAY K8644, levomycetin, cGMP, cAMP and GMP acted in the opposite way. All the SOD activtors had in common the property of being electron donors in the reactions with the light‐induced free radicals of eosin whereas the SOD inhibitors behaved as electron acceptors. The electron activity of SOD modulators correlated qualitatively with their regulating efficacy.