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Increased chloride efflux in fibroblasts from X‐linked muscular dystrophies and clones from Duchenne carriers
Author(s) -
Rugolo Michela,
Rocchi Mariano,
Lenaz Giorgio,
Romeo Giovanni
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81367-4
Subject(s) - duchenne muscular dystrophy , efflux , chemistry , chloride , biology , biochemistry , genetics , organic chemistry
Previous studies have suggested an increased chloride membrane permeability in Duchenne muscular dystrophy (DMD) fibroblasts. We report that an increased chloride efflux with respect to controls is present not only in fibroblasts from DMD, but also from two other X‐linked muscular dystrophies, Becker and Emery‐Dreifuss, as well as in clones from DMD carrier females. The latter observation suggests that, at least in DMD, the increased chloride efflux phenotype might be subject to lyonization.