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Changes in the proportions of histone H1° subtypes in brain cortical neurons
Author(s) -
Piña B.,
Suau P.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81328-5
Subject(s) - histone h1 , histone , biology , cerebral cortex , microbiology and biotechnology , brain cortex , cortex (anatomy) , neuroscience , endocrinology , genetics , gene
Histone H1° is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1°, H1°a and H1°b, are present in any tissue where the protein has been detected. We report here the first evidence of an age‐dependent change in the proportions of H1° subtypes. In rat cerebral cortex neurons the proportion of H1°a rises from 44% of total H1° at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1° at a significant rate.