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Immunological and biochemical aspects of malignant transformation and cell proliferation
Author(s) -
Grosse Richard,
Schön Rudolf,
Jantscherff Peter,
Pasternak Günter
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81320-0
Subject(s) - transformation (genetics) , cell growth , malignant transformation , chemistry , cancer research , microbiology and biotechnology , immunology , biology , biochemistry , gene
The meeting was opened by an introductory lecture of G. Pasternak (Berlin-Buch) summarizing problems of cell proliferation, differentiation and malignant transformation. Special attention was focussed on the role of one genes and one gene products as constituents of the ‘normal’ cellular genome and as functional components of a ‘mitogenic’ cascade normally controlling cell growth. The first topic of the meeting was concerned with immunological aspects of cellular proliferation and transformation. U. Karsten et al. (BerlinBuch) reported preliminary results concerning the production of monoclonal antibodies (MoAbs) against syngeneic rasor myc-transformed rat embryonic fibroblasts. Another topic of this section dealt with immunological reactivities as a consequence of malignant alterations. G. Petranyi (Budapest) reviewed the functional importance of several membranebound structures (e.g. CD antigen system LFA, HLA DR) of functionally defined cells (cytotoxic