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Estrogens as natural antioxidants of membrane phospholipid peroxidation
Author(s) -
Sugioka Katsuaki,
Shimosegawa Yasuko,
Nakano Minoru
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81293-0
Subject(s) - lipid peroxidation , estriol , phospholipid , chemistry , estrone , antioxidant , biochemistry , membrane , endocrinology , biology , hormone
Estrogens, such as estrone, estradiol and estriol, were tested as possible antioxidants of lipid peroxidation induced by Fe 3+ ‐ADP‐adriamycin or Fe 3+ ‐ADP‐ascorbate. The estrogens with phenolic structure possessed substantial activities with respect to the inhibition of lipid peroxidation. Concentrations of estradiol and estriol required to achieve 50% inhibition of membrane phospholipid peroxidation were about 4‐ and 6‐times that of α‐tocopherol, respectively