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Synthesis of the growth hormone‐regulated rat liver anti‐protease GHR‐P 63 is inhibited by acute inflammation
Author(s) -
Le Cam Ginette,
Le Cam Alphonse
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81286-3
Subject(s) - growth hormone receptor , inflammation , protease , medicine , endocrinology , messenger rna , in vitro , chemistry , in situ hybridization , receptor , growth hormone , hormone , biology , biochemistry , enzyme , gene
Synthesis of the growth hormone‐regulated anti‐protease GHR‐P 63 by rat hepatocytes was strongly reduced during acute inflammation. This decrease was detected 8 h after the onset of inflammation and reached a maximum after 24 h. A decrease in the GHR‐P 63 mRNA level measured by in vitro translation and by hybridization mainly accounted for the alteration of GHR‐P 63 synthesis. Besides this major pretranslational mechanism, inflammation also interfered with GHR‐P 63 synthesis at a posttranslational level. This was indicated by the production of abnormal immunoprecipitable species at early stages of the acute‐phase response.