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CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis
Author(s) -
Ruff Michael R.,
Martin Brian M.,
Ginns Edward I.,
Farrar William L.,
Pert Candace B.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81265-6
Subject(s) - infectivity , chemotaxis , human immunodeficiency virus (hiv) , monocyte , chemistry , receptor , block (permutation group theory) , virology , biochemistry , biology , immunology , virus , mathematics , geometry
The octapeptide Ala‐Ser‐Thr‐Thr‐Thr‐Asn‐Tyr‐Thr (peptide T) and two structural analogs are potent agonists of human monocyte chemotaxis, evincing identical rank potency orders as was previously shown for their inhibition of human immunodeficiency virus (HIV) envelope binding and T cell infectivity. Chemotactic activity could be inhibited by anti‐CD4 monoclonal antibodies (Mabs), but not other mononuclear cell Mabs. The core peptide required for chemotactic activity is a pentapeptide related to the sequence Thr‐Thr‐Asn‐Tyr‐Thr. Homologous pentapeptides, identified by computer search, were detected in several other non‐HIV‐related viruses as well as the neuropeptide vasoactive intestinal polypeptide (VIP). The CD4 molecule, therefore, appears to be a recognition molecule for a small signal peptide ligand whose active sequence is a homolog of peptide T [4–8] and which may be the neuropeptide VIP.