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Monoclonal antibody to fibronectin which inhibits extracellular matrix assembly
Author(s) -
Chernousov M.A.,
Faerman A.I.,
Frid M.G.,
Printseva O.Yu.,
Koteliansky V.E.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81255-3
Subject(s) - fibronectin , extracellular matrix , monoclonal antibody , chemistry , fibronectins , matrix (chemical analysis) , fibroblast , extracellular , microbiology and biotechnology , antibody , biochemistry , biology , immunology , in vitro , chromatography
A monoclonal antibody L8 specific to fibronectin was shown to inhibit fibronectin incorporation into the fibroblast extracellular matrix. Antibody L8 could not interact with fibronectin complexed with gelatin. The results suggest the existence of a specific site on the fibronectin molecule playing a critical role in the assembly of the fibronectin extracellular matrix. This site is located near the collagen‐binding domain.