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Glucagon‐like peptides activate hepatic gluconeogenesis
Author(s) -
Mommsen Thomas P.,
Andrews P.C.,
Plisetskaya Erika M.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81222-x
Subject(s) - gluconeogenesis , glucagon , medicine , endocrinology , chemistry , catfish , hormone , intracellular , biology , substrate (aquarium) , biochemistry , metabolism , fish <actinopterygii> , fishery , ecology
Piscine (anglerfish, catfish, coho salmon) glucagon‐like peptides (GLPs), applied at 3.5 nM, stimulate (1.1–1.9‐fold) flux through gluconeogenesis above control levels in isolated trout and salmon hepatocytes. Human GLP‐1 and GLP‐2 also activate gluconeogenesis, but to a lesser degree than their piscine counterparts. Minor increases of substrate oxidation are noticed at times of peak gluconeogenic activation through GLPs. These hormones, which are derived from the same precursor peptide as glucagon are more potent activators of gluconeogenesis than glucagon when applied at equimolar concentrations, and do not appear to employ cAMP or cGMP as the intracellular messenger in hepatic tissue.