Premium
One‐electron reduction of an anthracycline antibiotic carminomycin by a human erythrocyte redox chain
Author(s) -
Peskin Alexander V.,
Bartosz Grzegorz
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81218-8
Subject(s) - redox , chain (unit) , anthracycline , reduction (mathematics) , oxidation reduction , chemistry , antibiotics , biochemistry , medicine , inorganic chemistry , physics , cancer , geometry , mathematics , astronomy , breast cancer
Human erythrocyte membranes catalyse the NAD(P)H‐dependent generation of the semiquinone of an adriamycin‐type antibiotic carminomycin under anaerobic conditions. The maximal yield of the antibiotic radical is about 4‐fold higher in the presence of NADPH than of NADH. The possible significance of the antibiotic reduction to the semiquinone by a human erythrocyte membrane redox chain for the clinical usage of these antibiotics is discussed.