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Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca 2+ ,calmodulin‐dependent protein kinase II
Author(s) -
Ichimura Tohru,
Isobe Toshiaki,
Okuyama Tsueno,
Yamauchi Takashi,
Fujisawa Hitoshi
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81194-8
Subject(s) - activator (genetics) , biochemistry , monooxygenase , tyrosine , calmodulin , tryptophan , chemistry , protein kinase a , protein tyrosine phosphatase , enzyme , biology , amino acid , receptor , cytochrome p450
We have found that the 14‐3‐3 protein, an acidic neuronal protein, is substantially identical to the ‘activator’ protein [(1981) J. Biol. Chem. 256, 5404–5409] that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca 2+ ,calmodulin dependent protein kinase II. This finding is based on the remarkable similarity of both these proteins in physicochemical, biochemical and immunochemical properties, as well as on detection for the 14‐3‐3 protein of an activator activity towards tryptophan 5‐monooxygenase. The result suggests that the 14‐3‐3 protein plays a role in the regulation of serotonin and noradrenaline biosynthesis in brain.