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Evidence of an α 2 ‐macroglobulin‐like molecule in plasma of Salamandra salamandra Structural and functional similarity with human α 2 ‐macroglobulin
Author(s) -
Sallenave Jean-Michel,
Bellot Ricardo
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81186-9
Subject(s) - salamandra , macroglobulin , chemistry , molecule , biochemistry , monomer , biophysics , biology , salamander , zoology , organic chemistry , polymer
A high‐M r ( M r 750 000) α 1 ‐macroglobulin, obtained from Salamandra salamandra , is described. Salamander α 1 ‐macroglobulin is composed of two monomers of equal M r , which are composed of two polypeptide chains, each of M r 180 000, linked by disulfide bonds. The molecular parameters of this protein, its binding to trypsin and inactivation by methylamine suggest that salamander α 1 ‐macroglobulin is closely related to human α 2 ‐macroglobulin and to other related proteins described in the animal kingdom.