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A simple method for delineating well‐defined and variable regions in protein structures determined from interproton distance data
Author(s) -
Nilges Michael,
Clore G.Marius,
Gronenborn Angela M.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81181-x
Subject(s) - simple (philosophy) , variable (mathematics) , set (abstract data type) , data set , mathematics , biological system , mathematical analysis , statistics , computer science , biology , philosophy , epistemology , programming language
A simple method is described for identifying well‐defined regions in a set of protein structures calculated from experimental interproton distance restraints. Two different functions, one based on the mean global rms difference, the other on the distance variation between equivalent atoms in different residues, are used to distinguish ‘variable’ from ‘well‐defined’ regions. These functions are calculated in an iterative manner. The method is also capable of identifying several locally well‐defined regions whose relative positions are not well‐defined globally.