Premium
Aspirin induces alterations in low‐density lipoprotein and decreases its catabolism by cultured human fibroblasts
Author(s) -
Mazière C.,
Goldstein S.,
Moreau M.,
Mazière J.C.,
Polonovski J.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81054-2
Subject(s) - scavenger receptor , aspirin , catabolism , ldl receptor , chemistry , receptor , low density lipoprotein , in vitro , apolipoprotein b , lipoprotein , endocrinology , medicine , apolipoprotein e , scavenger , biochemistry , pharmacology , biology , cholesterol , metabolism , radical , disease
Aspirin interacts in vitro with human low‐density lipoprotein (LDL), which results in a decrease in free amino groups of apolipoprotein B and an increase of electrophoretic mobility of the particle. The aspirin‐treated LDL was less efficiently recognized than native LDL by the apo B/E receptor of fibroblasts. These results suggest that aspirin in long‐term treatment could influence the LDL‐receptor pathway. However, aspirin‐treated LDL did not bind to the scavenger receptor of macrophages.