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Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins
Author(s) -
Sternberg Michael J.E.,
Barton Geoffrey J.,
Zvelebil Marketa J.,
Cookson John,
Coates Anthony R.M.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81052-9
Subject(s) - epitope , glycoprotein , virology , gene , sequence (biology) , biology , antigen , peptide sequence , group specific antigen , computational biology , peptide , virus , genetics , biochemistry
Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte‐defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition to the env gene envelope glycoproteins being actively studied. The predictions of B‐ and T‐epitopes are refined by consideration of secondary structure prediction and inter‐isolate sequence variability to suggest peptides from env , gag and pol that would be the best vaccine candidates.