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Regulation of calcium uptake in synaptosomes from rat brain by DL‐2‐amino‐5‐phosphonovaleric acid
Author(s) -
Pastuszko Anna,
Yee Daniel K.,
Wilson David F.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81044-x
Subject(s) - calcium , biochemistry , amino acid , chemistry , receptor , stimulation , agonist , endogeny , biology , biophysics , endocrinology , organic chemistry
DL‐2‐Amino‐5‐phosphonovaleric acid stimulated calcium influx into synaptosomes isolated from rat brain. The increase in Ca 2+ permeability of the synaptosomal membranes induced by this amino acid is not markedly dependent on the membrane potential or Na + concentration. It is postulated that 2‐amino‐5‐phosphonovaleric acid is an agonist for a receptor(s) which regulates intraneuronal free calcium concentrations by modulating a selective calcium channel. The observed stimulation of calcium uptake may provide an assay system for purification of the endogenous ligand for this receptor and for characterization of its physiological role in neuronal function.