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Inositol 1,4,5‐trisphosphate and 5′‐GTP induce calcium release from different intracellular pools
Author(s) -
Henne Volkmar,
Piiper Albrecht,
Söling Hans-Dieter
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81037-2
Subject(s) - inositol , gtp' , intracellular , calcium , calcium in biology , inositol trisphosphate , chemistry , biophysics , microbiology and biotechnology , inositol phosphate , biochemistry , biology , receptor , enzyme , organic chemistry
It has been shown recently by several groups that 5′‐GTP can release calcium from intracellular compartments independently from inositol 1,4,5‐trisphosphate (Ins(1,4,5)P 3 ) by a mechanism which seems to be different from that used by Ins(1,4,5)P 3 . We report here for the first time that the 5′‐GTP‐sensitive and the Ins(1,4,5)P 3 ‐sensitive calcium pools reside in different intracellular compartments.