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Regulation of low density lipoprotein metabolism by 26‐hydroxycholesterol in human fibroblasts
Author(s) -
Lorenzo José L.,
Allorio Maria,
Bernini Franco,
Corsini Alberto,
Fumagalli Remo
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81022-0
Subject(s) - oxysterol , chemistry , homeostasis , cholesterol , biochemistry , metabolism , low density lipoprotein , ligand (biochemistry) , microbiology and biotechnology , receptor , biology
Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed‐back control of its biosynthesis. We report that 26‐hydroxycholesterol inhibits the specific binding, uptake and degradation of 125 I‐LDL in human fibroblasts. The effect is dose‐dependent, and saturation kinetics indicates a reduction of LDL‐binding sites with no effect on ligand affinity. The results support a possible role of 26‐hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.