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Trypanosomatid hydrogen peroxidase metabolism
Author(s) -
Penketh P.G.,
Kennedy W.P.K.,
Patton C.L.,
Sartorelli A.C.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80968-7
Subject(s) - metabolism , catalase , peroxidase , biochemistry , chemistry , enzyme , leishmania , biology , parasite hosting , world wide web , computer science
The rate of whole cell H 2 O 2 metabolism in several salivarian and stercorarian trypanosomes and Leishmania species was measured. These cells metabolized H 2 O 2 at rates between 2.3 and 48.2 nmol/10 8 cells per min depending upon the species employed. H 2 O 2 metabolism was largely insensitive to NaN 3 , implying that typical catalase and peroxidase haemoproteins are not important in H 2 O 2 metabolism. The metabolism of H 2 O 2 , however, was almost completely inhibited by N ‐ethylmaleimide. In representative species, H 2 O 2 metabolism was shown to occur through a trypanothione‐dependent mechanism.