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On an Mg 2+ ‐dependent interaction of actin with glyceraldehyde‐phosphate dehydrogenase The fundamental role of KCl in the organization of F‐actin
Author(s) -
Lanzara Vincenzo,
Grazi Enrico
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80961-4
Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , glyceraldehyde , dehydrogenase , actin , intracellular , chemistry , biophysics , phosphate , compartment (ship) , actina , biochemistry , enzyme , biology , cytoskeleton , cell , oceanography , geology
In the presence of Mg 2+ , the formation of actin filaments is hindered by glyceraldehyde‐3‐phosphate dehydrogenase. This effect, which increases with the square of Mg 2+ concentration, is counteracted by 0.15 M KCl. Thus KCl, at concentrations found in the intracellular compartment, appears to be strictly required for the correct formation of actin filaments in all tissues in which the glyceraldehyde‐phosphate dehydrogenase concentration is high.