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Effects of platelet‐activating factor on conversion of angiotensin I to II
Author(s) -
Kawaguchi Hideaki,
Yasuda Hisakazu
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80945-6
Subject(s) - angiotensin ii , platelet activating factor , renin–angiotensin system , chemistry , medicine , stimulation , endocrinology , angiotensin ii receptor type 1 , angiotensin receptor , biochemistry , receptor , blood pressure
We have studied the effects of platelet‐activating factor (alkyl‐acetyl‐GPC) on conversion of angiotensin I to II. Platelet‐activating factor (PAF) had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 30% of [ 125 I]angiotensin I to angiotensin II in the absence of PAF, but their activity was greatly stimulated in its presence. When PAF was added to pulmonary artery endothelial cells, the conversion of angiotensin I to II was enhanced up to 68%. Maximal stimulation without cellular damage was achieved at 10 −5 M PAF. LysoPAF did not stimulate the conversion of angiotensin I to angiotensin II at any concentration used.