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In vitro processing of rANF 7–28 ‐NH 2 by rat kidney homogenates
Author(s) -
Berman Judd M.,
Pelton John T.,
Cardin Alan D.,
Blankenship Dale T.,
Hassman C.Fred,
M. Chen Teng Man
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80906-7
Subject(s) - in vitro , kidney , chemistry , biochemistry , microbiology and biotechnology , chromatography , biology , endocrinology
The major rat kidney in vitro degradation products of the rat atrial natriuretic factor analog, H‐Cys 7 ‐Phe‐Gly‐Gly‐Arg‐Ile‐Asp‐Arg‐Ile‐Gly‐Ala‐Gln‐Ser‐Gly‐Leu‐Gly‐Cys‐Asn‐Ser‐Phe‐Arg‐Tyr 28 ‐NH 2 (with a Cys 27 ‐Cys 23 disulfide bridge), have been identified. The degradation products are the C‐terminal modified compounds rANF 7–27 , rANF 7–26 , and rANF 7–25 .