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Neurohypophyseal peptide inhibition of adenylate cyclase activity in fish gills The effect of environmental salinity
Author(s) -
Guibbolini Marielle E.,
Lahlou Brahim
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80883-9
Subject(s) - glucagon , gill , medicine , adenylate kinase , endocrinology , chemistry , cyclase , osmoregulation , catfish , basal (medicine) , salinity , seawater , euryhaline , enzyme , biology , biochemistry , fish <actinopterygii> , fishery , hormone , ecology , insulin
Adenylate cyclase activity was measured in plasma membranes prepared from gill epithelium of the rainbow trout ( Salmo gairdneri ) adapted to a large range of salinity (deionized water to seawater). Fish neurohypophyseal peptides (arginine‐vasotocin and isotocin) elicited a dose‐dependent inhibition (maximum for 10 −12 −10 −10 M which corresponds to physiological blood concentrations) of both basal and 10 −9 M glucagon stimulated enzyme activity. While basal activity was inhibited by up to 40% only in high salt media, glucagon‐stimulated activity was lowered by 60–100% for the same concentrations, in both freshwater and seawater.