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Cyclin (PCNA, auxiliary protein of DNA polymerase δ) is a central component of the pathway(s) leading to DNA replication and cell division
Author(s) -
Celis Julio E.,
Madsen Peder,
Celis Ariana,
Nielsen Henrik V.,
Gesser Borbala
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80865-7
Subject(s) - proliferating cell nuclear antigen , dna polymerase delta , dna replication , eukaryotic dna replication , dna polymerase , cyclin a , cell cycle , dna clamp , s phase , control of chromosome duplication , microbiology and biotechnology , biology , origin recognition complex , dna synthesis , replication factor c , dna , cyclin , biochemistry , cell , gene , rna , reverse transcriptase
Cyclin, also known as PCNA or the auxiliary protein of mammalian DNA polymerase δ, is a stable cell cycle regulated (synthesized mainly in S‐phase) nuclear protein of apparent M r 36 000 whose rate of synthesis correlates directly with the proliferative state of normal cultured cells and tissues. Cyclin (PCNA) is absent or present in very low amounts in normal non‐dividing cells and tissues, but it is synthesized in variable amounts by proliferating cells of both normal and transformed origin. All available information indicates that this ubiquitous and tightly regulated DNA replication protein is a central component of the pathway(s) leading to DNA replication and cell division.