Premium
Influence of prostaglandins on the lipid transfer between human high density and low density lipoproteins
Author(s) -
Muzya G.I.,
Korobkova E.N.,
Golovanova N.K.,
Bergelson L.D.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80849-9
Subject(s) - chemistry , cholesterol , phosphatidylcholine , high density lipoprotein , plant lipid transfer proteins , prostaglandin , lipoprotein , endocrinology , stimulation , medicine , human plasma , biochemistry , chromatography , biology , phospholipid , membrane , gene
Prostaglandin (PG) E 1 was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL 3 ) to low density lipoproteins (LDL). The enhancement effect of PGE 1 , on the interlipoprotein lipid transfer was seen at low PG concentrations under conditions of spontaneous exchange as well as in the presence of lipoprotein‐depleted plasma, or partly purified plasma lipid exchange protein. PGE 2 and PGF 2α showed no significant influence on the interlipoprotein lipid transfer. Evidence is presented suggesting that the PGE 1 ‐induced stimulation of interlipoprotein lipid exchange results in enhancement of LCAT‐catalyzed cholesterol esterification in plasma. It is proposed that the effect of PGE 1 is due to the previously described PGE 1 ‐induced reorganization of the HDL surface [(1984) FEBS Lett. 173, 291‐293] and that PG‐lipoprotein interaction may be a factor regulating cholesterol homeostasis.