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Peritonitis induces the synthesis of 1α,25‐dihydroxyvitamin D 3 in macrophages from CAPD patients
Author(s) -
Hayes M.E.,
O'Donoghue D.J.,
Ballardie F.W.,
Mawer E.B.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80836-0
Subject(s) - continuous ambulatory peritoneal dialysis , metabolite , peritoneal dialysis , peritonitis , metabolism , peritoneum , calcitriol , active metabolite , vitamin d and neurology , medicine , endocrinology , chemistry , gastroenterology , pathology
Metabolism of 25‐[ 3 H]hydroxyvitamin D 3 was studied in peritoneal macrophages from renal failure patients on continuous ambulatory peritoneal dialysis (CAPD). Cells from 5 out of 8 patients with a history of peritonitis produced significant amounts of a metabolite chromatographically identical to 1α,25(OH) 2 D 3 ; but none was produced by cells from non‐infected patients. The evidence strongly suggests that peritoneal macrophages stimulated by infection can metabolise 25OHD 3 to the active vitamin D 3 metabolite, 1α,25(OH) 2 D 3 , when maintained in short‐term primary culture.