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Histidine‐rich glycoprotein is evolutionarily related to the cystatin superfamily
Author(s) -
Koide Takehiko,
Odani Shoji
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80748-2
Subject(s) - cystatin , glycoprotein , kininogen , cystatin c , histidine , chemistry , biochemistry , biology , microbiology and biotechnology , amino acid , kallikrein , enzyme , renal function
A new member of the cystatin superfamily is introduced. Human plasma histidine‐rich glycoprotein (HRG) was found to contain 2 cystatin‐like sequences in tandem in the N‐terminal region. Domain 1 (residues 1–112) was most homologous to domain 1 of the heavy chain of human kininogen and domain 2 (residues 113–225) was most homologous to human cystatin S as well as other cystatins and domain 3 of the heavy chain of kininogen, suggesting that the cystatin domains of HRG may represent a hitherto unknown binary form (or intermediate molecule) composed of 2 cystatin domains, and evolutionarily intermediate between the cystatin and the kininogen families.