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Activation of metallothionein expression is potentiated by DNA sequences present in the herpes simplex virus thymidine kinase gene
Author(s) -
Lewis John A.,
di Girolamo Adele Bendicenti
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80681-6
Subject(s) - thymidine kinase , gene , herpes simplex virus , transfection , metallothionein , biology , interferon , microbiology and biotechnology , thymidine , gene expression , cell culture , virology , dna , virus , biochemistry , genetics
A mouse cell line (Ltk— aprt—) which is resistant to the anti‐viral effects of interferon also has a reduced ability to synthesize metallothionein on exposure to cadmium. Like the ability to respond to interferon, cadmium‐induced metallothionein synthesis is restored to wild‐type levels in clones obtained by introducing a thymidine kinase gene into Ltk— aprt— cells. Transfection of other genes does not have such an effect. Since metallothionein expression is also activated by interferon the results suggest that the regulation of several genes which are responsive to interferon can be modulated by specific sequences present in the Herpes virus thymidine kinase gene.