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Contraction‐associated translocation of protein kinase C in rat skeletal muscle
Author(s) -
Richter Erik A.,
Cleland Perry J.F.,
Rattigan Stephen,
Clark Michael G.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80669-5
Subject(s) - cytosol , skeletal muscle , protein kinase a , chromosomal translocation , contraction (grammar) , protein kinase c , chemistry , stimulation , sciatic nerve , medicine , muscle contraction , soleus muscle , kinase , endocrinology , biology , biochemistry , anatomy , enzyme , gene
Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time‐dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius‐plantaris‐soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction‐initiated changes in muscle metabolism.