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Hormonal regulation of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase: Kinetic models
Author(s) -
Goldstein B.N.,
Ivanova A.N.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80665-8
Subject(s) - phosphofructokinase 2 , fructose 2,6 bisphosphate , chemistry , fructose , hormone , biochemistry , fructose 1,6 bisphosphatase , kinase , glycolysis , enzyme , microbiology and biotechnology , biology , phosphofructokinase
A graphical method to reveal the so‐called ‘critical fragments’ in schemes of biochemical systems is considered. These fragments produce multiple steady states or self‐oscillations in systems. As an example, the bifunctional enzyme, 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase, regulated by glucagon through enzyme phosphorylation, is discussed. It is shown that this enzyme may act as a metabolic switching mechanism in discontinuous or oscillatory regimes, depending on the specific structure of its kinetic scheme. The boundaries of concentrational and parameter domains for these critical phenomena are also predicted.