Premium
Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies
Author(s) -
Ono Yoshitaka,
Fuji Tomoko,
Ogita Kouji,
Kikkawa Ushio,
Igarashi Koichi,
Nishizuka Yasutomi
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80564-1
Subject(s) - subspecies , identification (biology) , chemistry , protein kinase c , computational biology , kinase , biology , biochemistry , zoology , botany
Three types of cDNA clone of the protein kinase C family termed δ, ϵ and ξ were newly identified by molecular cloning and sequence analysis. These members have a common structure that is closely related to, but clearly different from the other four known members of the family which have α‐, βI‐, βII‐ and γ‐sequences, although the ξ‐cDNA available at present does not contain a complete reading frame for a protein kinase C molecule. The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli.