Premium
Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I) · poly(C) in human amnion cells (UAC)
Author(s) -
Premecz György,
Markovits Andrea,
Bagi György,
Farkas Tibor,
Földes István
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80541-0
Subject(s) - vesicular stomatitis virus , inositol , activator (genetics) , chromosomal translocation , biochemistry , interferon , protein kinase c , enzyme , kinase , chemistry , phospholipid , biology , microbiology and biotechnology , virus , virology , gene , receptor , membrane
Polyinosinic‐polycytidylic acid, a potent inducer of interferon (IFN) production and activator of some IFN‐induced enzymes, inhibits [ 3 H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.