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The mechanism of cytochrome oxidase and other reaction centres for electron/proton pumping
Author(s) -
Williams R.J.P.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80539-2
Subject(s) - cytochrome c oxidase , proton , chemistry , electron transfer , oxidase test , azurin , electron transport complex iv , enzyme , biophysics , biochemistry , photochemistry , biology , physics , quantum mechanics
The functional significance of the metal centres of cytochrome oxidase is deduced from the ways in which the centres are bound into its peptides. To this end use is made of structural knowledge of other metallo‐proteins for dioxygen binding, haemocyanin and haemoglobin, and for electron transfer, cytochromes b and azurin. The order and manner in which the motions of helical sections of the oxidase are linked to proton pumping are suggested and a comparison is made with other proton pumps, for example that of ATP synthetases.