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On the role of microsomal aldehyde dehydrogenase in metabolism of aldehydic products of lipid peroxidation
Author(s) -
Antonenkov Vasily D.,
Pirozhkov Sergej V.,
Panchenko Leonid F.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80484-2
Subject(s) - lipid peroxidation , microsome , aldehyde dehydrogenase , chemistry , biochemistry , aldehyde , microsoma , enzyme , catalysis
To elucidate a possible role of membrane‐bound aldehyde dehydrogenase in the detoxication of aldehydic products of lipd peroxidation, the substrate specificity of the highly purified microsomal enzyme was investigated. The aldehyde dehydrogenase was active with different aliphatic aldehydes including 4‐hydroxyalkenals, but did not react with malonic dialdehyde. When Fe/ADP‐ascorbate‐induced lipid peroxidation of arachidonic acid was carried out in an in vitro system, the formation of products which react with microsomal aldehyde dehydrogenase was observed parallel with malonic dialdehyde accumulation.