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Thyroid hormone uptake into the cell and its subsequent localisation to the mitochondria
Author(s) -
Hafner Roderick P.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80464-7
Subject(s) - thyroid hormone receptor , hormone , hormone receptor , thyroid , mitochondrion , receptor , endocytosis , thyroid hormone receptor beta , thyroid hormone receptor alpha , adenine nucleotide translocator , cell , biology , medicine , endocrinology , chemistry , microbiology and biotechnology , biochemistry , cancer , breast cancer
The nature of thyroid hormone uptake into the cell and the possible involvement of the serum carrier proteins and receptor‐mediated endocytosis in this process are reviewed. The evidence that there is a specific thyroid hormone‐binding receptor in the inner mitochondrial membrane and the relation of this to the adenine nucleotide translocator is discussed. Direct effects of thyroid hormone on mitochondrial function that might be mediated by such a receptor are also considered.