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Linear relationships between mitochondrial forces and cytoplasmic flows argue for the organized energy‐coupled nature of cellular metabolism
Author(s) -
Berry M.N.,
Gregory R.B.,
Grivell A.R.,
Henly D.C.,
Phillips J.W.,
Wallace P.G.,
Welch G.R.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80448-9
Subject(s) - mitochondrion , energy metabolism , cytoplasm , metabolism , enzyme , biochemistry , redox , metabolic pathway , microbiology and biotechnology , biophysics , urea , membrane , inner mitochondrial membrane , biology , phosphorylation , chemistry , organic chemistry , endocrinology
We have studied rates of formation of glucose, urea and lactate by isolated hepatocytes incubated with a variety of inhibitors of energy transduction. Linear relationships have been found between these metabolic rates and mitochondrial forces (membrane, redox and phosphorylation potentials). The findings are suggestive of extensive enzyme organization within these metabolic pathways.