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Induction and activation of tissue transglutaminase during programmed cell death
Author(s) -
Fesus Laszlo,
Thomazy Vilmos,
Falus Andras
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80430-1
Subject(s) - tissue transglutaminase , apoptosis , programmed cell death , enzyme , immunohistochemistry , chemistry , microbiology and biotechnology , biology , medicine , biochemistry , immunology
During the involution of lead nitrate‐induced hyperplasia in rat liver a significant increase of transglutaminase activity, enzyme concentration, transglutaminase messenger RNA and protein‐bound ε‐(γ‐glutamyl)lysine (product of transglutaminase action) coincided with programmed death (apoptosis) of hepatocytes. Immunohistochemical examination showed the appearance of transglutaminase in apoptotic hepatocytes. An increased transglutaminase level was also detected during glucocorticoid‐induced apoptosis of rat thymocytes.