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Induction of c‐ fos proto‐oncogene by a chemotactic peptide in human peripheral granulocytes
Author(s) -
Itami Makiko,
Kuroki Toshio,
Nose Kiyoshi
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80388-5
Subject(s) - pertussis toxin , chemotaxis , microbiology and biotechnology , peptide , protein kinase a , chemistry , protein kinase c , messenger rna , kinase , biology , g protein , biochemistry , receptor , gene
The chemotactic peptide, fMet‐Leu‐Phe (fMLP), induced proto‐oncogene c‐& f ; os MRNA in purified human peripheral granulocytes. The induction was transient, and was inhibited by pertussis toxin or by an inhibitor of protein kinase C. These results suggest that activation of a guanine nucleotide‐binding protein and of protein kinase C is involved in c‐& f ; os induction in granulocytes.