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The 3′‐orf protein of human immunodeficiency virus 2 shows sequence homology with the bel 3 gene of the human spumaretrovirus
Author(s) -
Maurer Bernd,
Flügel Rolf M.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80387-3
Subject(s) - homology (biology) , gene , virology , sequence homology , biology , genetics , human immunodeficiency virus (hiv) , sequence (biology) , group specific antigen , peptide sequence
The primary amino acid sequence within a domain of 89 residues of the central part of the 3′‐orf protein (p27 3′‐orf) of human immunodeficiency virus (HIV‐2) shares homology with the middle and carboxy‐terminal portion of the bel 3 gene product of human spumaretrovirus (HSRV). In addition, a limited region of the tat protein of HIV‐2 but not HIV‐1 shows a 28% degree of homology to the deduced protein sequence of the bel 1 gene product of HSRV. Comparison between the viral sequences suggests that the 3′‐orf and bel 1 gene product of HSRV could serve similar functions to those in HIV‐2.