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Characterization of glucacon receptors in Golgi fractions of fetal rat liver
Author(s) -
de Diego Juana G.,
Alvarez Elvira,
Blázquez Enrique
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80381-2
Subject(s) - glucagon , golgi apparatus , receptor , glucagon receptor , medicine , endocrinology , fetus , biology , chemistry , biochemistry , cell , hormone , pregnancy , genetics
The present study was designed to determine if Golgi fractions from fetal rat liver contain glucagon receptors and to characterize the properties of such receptors. Purification patterns of liver plasma membranes and Golgi fractions from fetal and adult rats were similar, as verified by morphological and biochemical approaches. Glucagon binding was greater in plasma membranes of adult than fetal rats, while in Golgi fractions glucagon binding was similar in both groups. The modifications in glucagon binding reflect changes in glucagon receptors. Glucagon association and glucagon receptor inactivation by liver membranes were similar in the two groups of animals, while glucagon degradation was lower in fetal than in adult rats.