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Biosynthesis and activity of DNA polymerase throughout the mitotic cycle of Physarum polycephalum
Author(s) -
MacNicol A.M.,
Banks G.R.,
Cox R.A.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80350-2
Subject(s) - physarum polycephalum , dna polymerase , polymerase , physarum , mitosis , microbiology and biotechnology , dna polymerase i , dna synthesis , biochemistry , dna , biology , chemistry , polymerase chain reaction , gene , reverse transcriptase
Measurements of DNA polymerase protein levels and polymerase activity through the naturally synchronous mitotic cycle of Physarum polycephalum show that active DNA polymerase‐α is synthesized throughout the G 2 phase, in step with the profile of general protein biosynthesis. Three main components of P. polycephalum DNA polymerase of 200, 112 and 70 kDa were found to be immunologically related.