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Volatile anesthetics depress the depolarization‐induced cytoplasmic calcium rise in PC 12 cells
Author(s) -
Kress Hans G.,
Eckhardt-Wallasch Heike,
Tas Piet W.L.,
Koschel Klaus
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80346-0
Subject(s) - halothane , isoflurane , enflurane , methoxyflurane , chemistry , depolarization , calcium , biophysics , fura 2 , fluorescence , intracellular , anesthesia , biochemistry , medicine , biology , cytosol , organic chemistry , enzyme , physics , quantum mechanics
In the rat pheochromocytoma cell line PC 12, the effects of four volatile anesthetics (halothane, isoflurane, enflurane, methoxyflurane) on the K + ‐evoked intracellular calcium ([Ca 2+ ] i ) rise were investigated using the Ca 2+ ‐sensitive fluorescence dye fura‐2. The [Ca 2+ ] i rise was depressed, at clinical concentrations, by all anesthetics with almost identical aqueous IC 50 values. The study extends to neuronal cells the observation made previously in cardiac tissue that volatile anesthetics may interfere with Ca 2+ fluxes through voltage‐gated channels.