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The preparation and properties of novel reversible polymer‐protein conjugates 2‐ω‐Methoxypolyethylene (5000) glycoxymethylene‐3‐methylmaleyl conjugates of plasminogen activators
Author(s) -
Garman Andrew J.,
Barret Kalindjian S.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80319-8
Subject(s) - conjugate , chemistry , polymer , combinatorial chemistry , biophysics , organic chemistry , biology , mathematical analysis , mathematics
The preparation of a reagent capable of reversibly attaching polyethylene glycol to proteins and the use of this material in modifying the plasminogen activators urokinase‐ and tissue‐type plasminogen activator are described. The characterisation and the reversible nature of these protein‐polymer conjugates are discussed, and some of the in vitro properties of these modified enzymes are explored.