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Epidermal growth factor as a new regulator of induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids
Author(s) -
Kido Hiroshi,
Fukusen Naomi,
Katunuma Nobuhiko
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80293-4
Subject(s) - tyrosine aminotransferase , endocrinology , epidermal growth factor , medicine , glucocorticoid , dexamethasone , endogeny , tyrosine , biology , chemistry , enzyme inducer , enzyme , biochemistry , receptor
Epidermal growth factor (EGF) dose‐dependently enhanced the induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids in primary cultures of adult rat hepatocytes without itself having any effect on these enzymes in the absence of glucocorticoids. The amplifications were observed even with dexamethasone at high concentrations (10 −6 M−10 −5 M) that had a maximal effect. EGF had no effect on induction of tyrosine aminotransferase by glucagon or Bt 2 cAMP. The effect of EGF was also observed in adrenal‐ectomized and submaxillar gland‐ectomized rats. These results suggest that EGF is an endogenous amplifier of the action of glucocorticoids.