Premium
Ile‐Ser‐bradykinin (T‐kinin) and Met‐Ile‐Ser‐bradykinin (Met‐T‐kinin) are released from T‐kininogen by an acid proteinase of granulomatous tissues in rats
Author(s) -
Sakamoto Wataru,
Satoh Fumihiko,
Gotoh Katsuhiro,
Uehara Soichiro
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80267-3
Subject(s) - kinin , bradykinin , kininogen , chemistry , biochemistry , receptor
An acid proteinase of granulomatous tissues in rats with carrageenin‐induced inflammation released kinin from T‐kininogen. The kinin isolated by n ‐butanol extraction was separated by reverse‐phase high‐performance liquid chromatography into T‐kinin and a T‐kinin derivative. From determination of its amino acid composition and its immunoreactivity toward anti‐bradykinin antiserum, the T‐kinin derivative was identified as Met‐Ile‐Ser‐bradykinin (Met‐T‐kinin).