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Role of Mg 2+ in the ribozyme system
Author(s) -
Toh Hiroyuki,
Imamura Akira,
Kanda Katsuya
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80235-1
Subject(s) - ribozyme , vs ribozyme , rna splicing , mammalian cpeb3 ribozyme , ligase ribozyme , hairpin ribozyme , catalysis , chemistry , rna , biochemistry , gene
Recently, several kinds of catalytic activities have been identified from L‐19 IVS RNA or ‘ribozyme’. In the catalytic process of ribozyme, Mg 2+ is required. We investigated the role of Mg 2+ by molecular orbital calculation. Based on the results of the calculation, a model for the self‐splicing reaction was constructed.