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Human protein S cDNA encodes Phe‐16 and Tyr 222 in consensus sequences for the post‐translational processing
Author(s) -
van Amstel Hans K.Ploos,
van der Zanden A.Linda,
Reitsma Pieter H.,
Bertina Rogier M.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80217-x
Subject(s) - complementary dna , coding region , asparagine , amino acid , untranslated region , genetics , biology , consensus sequence , peptide sequence , microbiology and biotechnology , messenger rna , gene
Partial cDNAs coding for human protein S were isolated from a pUC9 human liver cDNA library. Together, the overlapping clones span a (partial) 5′‐non‐coding region, and the complete protein S coding and 3′‐untranslated regions. The derived amino acid sequence deviates at five positions from two previously reported protein S sequences. Two of these differences (Phe instead of Leu at position — 16 and Tyr instead of Asp at position 222) are found in regions that are important for the post‐translational modification of protein S, the γ‐carboxylation of glutamic acid and the hydroxylation of asparagine, respectively.